Immunologic responses to isocyanates in sensitized asthmatic subjects.
نویسندگان
چکیده
منابع مشابه
Occupational asthma caused by isocyanates: patterns of asthmatic reactions to increasing day-to-day doses.
Inhalation challenges to isocyanates are conducted in specialized centers to confirm occupational asthma. The pattern of asthmatic reactions due to consecutively increasing daily doses of isocyanates is unknown. We conducted a study involving 24 subjects who had undergone specific inhalation challenges to isocyanates (toluene diisocyanate [TDI], n = 8; hexamethylene diisocyanate [HDI], n = 10; ...
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To elucidate the role and mechanism of action of interleukin (IL)-10 in regulating airway smooth muscle (ASM) responsiveness in the atopic asthmatic state, isolated rabbit tracheal ASM segments were passively sensitized with serum from atopic asthmatic patients or nonatopic nonasthmatic (control) subjects in both the absence and presence of an anti-IL-10 receptor blocking antibody (Ab). Relativ...
متن کاملStudies on antigens useful for detection of IgE antibodies in isocyanate-sensitized workers.
Toluene diisocyanate was conjugated by two different methods to human serum albumin. These conjugates were used as antigens in the radio-allergo-sorbent-test (RAST) for detection of IgE antibodies in sera of isocyanate-sensitized persons. Chemical analyses have shown that conjugates containing 18-28 mol of isocyanate residues per mol protein were more potent antigens than those containing great...
متن کاملHypersensitivity pneumonitis after exposure to isocyanates.
Four patients exposed to isocyanate vapour developed dyspnoea associated with restriction and reduced gas transfer as well as moderate airways obstruction on lung function testing. In one patient bilateral radiographic shadowing was present and an open lung biopsy was performed. The microscopic appearances ranged from acute inflammation to end-stage fibrosis but the centribular accentuation of ...
متن کاملOccupational asthma due to isocyanates.
162 subjects who had been exposed to isocyanates, who had developed symptoms during the exposure period, or in the evening or night and, therefore, had a history compatible with isocyanate-induced asthma, were studied with inhalation challenge testing to isocyanates (toluene diisocyanate and methylene diphenyl diisocyanate) and methacholine, because they were suspected of having occupational as...
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ورودعنوان ژورنال:
- Chest
دوره 109 3 Suppl شماره
صفحات -
تاریخ انتشار 1996